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Diabetics with type 1 disease, that is insulin-dependent, must receive insulin injections for the rest of their lives since their own pancreatic tissue fails to produce sufficient quantities of this vital hormone. Efforts to solve this problem include whole organ pancreas transplants and transplants of the insulin-producing beta pancreatic islet cells.

One problem is a large enough supply of these beta islet cells. Enter endocrinologists and regenerative medicine researchers at the Netherland’s Leiden University who have developed methods to better isolate large numbers of stem cells that have been transformed into the insulin-producing beta islet cells. Their studies are now published in the journal Science Translational Medicine.

Their technique employs density gravity centrifuges to optimally isolate just those stem-cell derived islet cells that will capably produce insulin once transplanted into their human recipients. Their system has undergone successful preclinical trials in diabetic mice. It is more effective and efficient than other cell sorting techniques, and it can be scaled up to produce the large qualities of beta islet cells that will be required for human trials.

https://www.science.org/doi/10.1126/scitranslmed.adl4390

https://medicalxpress.com/news/2025-04-technique-architecture-insulin-islet-cells.html#google_vignette

#diabetes #insulin #stemcells #betaisletcells #centrifugation