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What if a single blood test could reveal a hidden, lifelong risk for heart disease that affects one in five people? This risk factor, Lipoprotein(a), is almost entirely determined by your genes and doesn't improve with diet or exercise. In this episode, I break down everything you need to know about Lp(a) and why asking your doctor for this simple, once-in-a-lifetime test could be a game-changer for your health.

CHAPTERS:
00:00 - Introduction
00:44 - What is Lp(a)?
01:30 - The Genetics of Lp(a)
02:27 - 4: Kringle Repeats
03:20 - 5: Epidemiology
04:06 - 6: Global Impact of Lp(a)
04:50 - 7: Why It Actually Causes Increased Risk
05:50 - 8: Atherogenic Pathway
06:31 - 9: Lp(a) and Plaque Stability
07:22 - 10: Pro Inflammatory Pathway
07:57 - 11: Local Inflammation Doesn’t Always Mean Systemic Inflammation
09:03 - 12: Pro Thrombotic Pathway
10:04 - 13: Clinlical Manifestations
10:48 - 14: Screening Recommendations
11:37 - 15: Measuring Lp(a)
13:20 - 16: Defining High Risk Lp(a)
14:32 - 17: Current Management Principles
15:11 - 18: Lowering LDL
17:08 - 19: Statins, Ezetimibe, and Bempedoic Acid
18:25 - 20: PCSK9i and Omega 3’s
19:31 - 21: Therapies to Avoid
20:39 - 22: RNA Based Treatments
21:17 - 23: Antisense Oligonucleotides- Pelacarsen
22:00 - 24: siRNAs- Olpasiran
22:50 - 25: Muvalaplin- An Oral RNA Option
23:28 - 26: Lp(a)/Diabetes Paradox
24:17 - 27: High Risk Populations
25:18 - 28: Key Unanswered Questions
25:53 - 29: Key Takeaways
26:36 - 30: The Future

SELECTED REFERENCES:
https://doi.org/10.3390/ph18050753
https://doi.org/10.1016/j.jacl.2024.03.001
https://doi.org/10.37532/1755-5310.2023.15(S16).395
https://doi.org/10.1161/ATV.0000000000000147
https://doi.org/10.1016/j.ajpc.2024.100651

*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.