Why do Europe’s brightest founders still feel forced to leave for Silicon Valley—no matter how much money or talent we pour into the region?
Every year, ambitious startups across Europe and CEE struggle to scale—not for lack of ideas, but because of invisible barriers that keep global success out of reach.

Is it really just about capital—or is there a deeper mindset and playbook that only a handful of founders ever discover?

In this episode, venture insider Enis Hulli (General Partner at e2vc, investor in 40+ startups, 3 unicorns, and builder of bridges from Istanbul to the Bay) pulls back the curtain on the real reasons US-based startups keep winning—and how founders from Turkey, Eastern Europe, and beyond can finally turn the tables.

🎧 Watch now to learn:
1️⃣ The “power law” that decides which founders build generational companies—and why most never see it coming
2️⃣ Why relationships, not pitch decks, determine who actually gets funded—and how to break through if you don’t have the right connections
3️⃣ How emotional resilience and founder mindset shape the fate of entire regions—not just individuals
4️⃣ The little-known risks of playing the European “safe game”—and how to engineer luck for outsized results
5️⃣ Tactical lessons on team building, brand, and why your anti-portfolio (the deals you missed) might matter even more than your winners

👤 About Enis Hulli
Enis is General Partner at e2vc, a leading early-stage venture fund focused on scaling tech startups from Emerging Europe to global markets. With investments in 40+ companies (including three unicorns), he’s spent his career helping founders unlock the path from local player to world-class leader.

💬 Quotes That Might Shift Your Thinking:
(01:30:44) “I don’t think we’ll see founders choosing Europe over the US in our…”
(01:34:37) “There are twenty different ways to kill a reputation on any side of the…”
(01:38:31) “To avoid complacency, I surround myself with people who make me feel like I…”

🧭 Timestamps to Explore:
(00:16:58) How the Bay Area’s Talent Network Effect Became Unstoppable
(00:20:48) Work-Life Balance vs. Blitzscaling—What It Really Takes to Go from Zero to One
(00:25:43) Why Founders Trump Pitch Decks Every Time
(00:30:38) The Perils of Planning for an Exit Too Soon
(00:34:34) The Three Qualities Every VC Looks For—And Why Mindset Still Wins
(00:40:30) How IPO Markets Shape (and Break) Venture Capital
(00:43:52) Fundraising Mistakes That Kill FOMO and Crush Deals
(01:12:58) Why Bay Area Mindset Still Outpaces Europe’s Best
(01:30:44) The Real Reason Europe Loses Its Unicorns
(01:34:37) Reputation, Relationships, and the Hidden Dangers of VC Control
(01:38:31) How Top Investors Avoid Complacency and Stay Hungry

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Still trying to optimize your health with guesswork and generic advice?
Most people settle for “one-size-fits-all” supplements and hope for the best-missing out on the breakthroughs that only real data and personalization can offer.
In a world flooded with empty promises, few realize how quickly tailored, science-backed solutions can transform energy, focus, and longevity.

Enter Vadim Fedotov—ex-pro athlete, CEO, and co-founder of Bioniq, the health tech company bringing truly personalized care to the world’s top leaders, innovators, and athletes.

In this eye-opening conversation, Vadim reveals why your biology is as unique as your fingerprint—and why the future belongs to those who personalize, measure, and adapt.
Discover the systems, mindsets, and science behind optimizing human potential—without wasting time, money, or hope on outdated approaches.

🎧 Watch now to explore:
1️⃣ The fatal flaw in “one-size-fits-all” wellness—and how personalization is rewriting the rules
2️⃣ How AI, data, and regular feedback loops empower you to outpace your peers—at work, in health, and in life
3️⃣ Lessons from elite sports: why discipline, team dynamics, and feedback matter in business
4️⃣ The “feedback loop” secret that’s changing the supplement industry forever
5️⃣ Vadim’s vision for a future where your fridge, wearable, and AI coach work together to help you thrive

👤 About Vadim Fedotov
Vadim is the co-founder and CEO of Bioniq, former CEO at Groupon, and a former professional basketball player with the German National Team and Buffalo Bulls. Driven by his passion for health optimization, he’s building a global, interdisciplinary network of thought leaders to put cutting-edge, personalized care within everyone’s reach.

💬 Quotes That Might Shift Your Thinking:
(00:08:27) "Personalized health isn't a trend; it's the future of wellness."

(00:15:54) "There is no single right diet, exercise, or routine—every body truly needs something different."

(00:44:11) "Personalization in health is not a luxury anymore; it’s quickly becoming a necessity."

(01:06:26) "You only fail when you give up—resilience defines success."

(01:23:21) "Seventy percent of your health is determined by nutrition, not pharmaceuticals or medicine."

🧭 Timestamps to Explore:
(00:03:32) Why Visionary Leaders and Families Move to Dubai
(00:08:27) Personalizing Health Revolution How Data-Driven Wellness Changes Everything
(00:09:27) Health as the New Wealth Post-Covid Insights
(00:15:52) Busting Health Myths There’s No One-Size-Fits-All
(00:18:28) Data Over Opinion Navigating Health Complexity
(00:21:03) Olympic Research Sparks Personalized Health Innovation
(00:23:51) When Obvious Solutions Don’t Exist—The Birth of Bioniq
(00:25:40) When a "Dumb Idea" Becomes a Massive Opportunity
(00:31:01) Setting Personal Health Goals With AI and Data
(00:34:40) Real-World Feedback Loops Cut Through Wellness Hype
(00:40:07) Data-Driven Breakthroughs That Save Lives
(00:44:11) Why Health Personalization Is Now a Necessity
(00:54:31) Leadership, Discipline, and Lessons from Elite Sports
(01:01:04) Finding Pride and Resilience Against All Odds
(01:23:21) Redesigning Healthcare Starting With Nutrition

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How do you lead at the cutting edge of health, data, and AI—while staying deeply human?

Angeli Möller has led global data science teams across pharma giants, co-founded one of Europe’s most ambitious AI alliances, and now builds high-performance biotech strategies with precision. But what truly sets her apart isn’t just her technical fluency—it’s her clarity, courage, and care in how she builds teams, solves problems, and pushes the boundaries of innovation.

In this episode, Angeli opens up about the quiet frustrations that fuel her mission, the invisible cost of ignoring innovation, and the principles that guide her client work today. Whether you’re an investor, founder, or policymaker, her journey will reshape how you think about leadership, AI, and what truly moves the needle in healthcare.

Here’s what you’ll take away:

• Why most AI projects fail—and how to spot the ones that won’t.
• How to lead technical teams with vision, warmth, and accountability.
• Why proprietary data matters more than fancy algorithms.
• What real innovation feels like—and how to know when you’re missing it.

At the center of it all: a calm, fiercely smart leader who sees through the noise and builds what matters.

As she says:
“Start with the real problem. If you don’t understand the problem, AI won’t help you.”

Timestamps & Topics

📌 (01:08) Missed AI Integration Costs – “It’s faster, more effective, cheaper—but it’s not part of the core business yet.”

📌 (03:57) AI vs. Real-World Drug Impact – “The question isn’t: does it use AI? It’s: does the medicine work?”

📌 (04:48) Post-Hype AI Fallout in Pharma – “Fraud led to disillusionment. And investors paid the price.”

📌 (06:39) Corporate Blind Spots in Innovation – “It’s a danger in business to think there’s nothing to learn from others.”

📌 (09:40) Building a European AI Alliance – “At first, pharma didn’t take us seriously. That changed with the data.”

📌 (11:02) Data Ethics and Regulatory Risk – “You can massively hurt your business through accidental bias.”

📌 (13:19) Data Access for Rare Diseases – “The only solution is to make that data safely available.”

📌 (15:22) Leadership Shift: From Bayer to Startup – “It felt too obvious. I needed something riskier, more meaningful.”

📌 (21:23) Three Core Leadership Traits – “Vision. Technical understanding. And knowing when to bring in others.”

📌 (22:27) Frictionless Health Tech Adoption – “It’s inevitable. The economics—and behavior nudges—are already shaping it.”

This episode offers more than insight—it’s a playbook for building what’s next in health, tech, and leadership.

👉 Listen now, and share it with someone ready to shape the future.

🎙️ With over 200 interviews, panels, and livestreams, Beginner’s Mind ranks in the Top 10% globally—and is recognized as the leading deep tech podcast for biotech, AI, and scientific innovation.

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Most founders add layers to gain control. Reed Hastings built an empire by removing them.

This episode unpacks No Rules Rules—the leadership playbook behind Netflix’s rise from a DVD mail service to a global entertainment powerhouse. Co-authored by founder Reed Hastings and INSEAD professor Erin Meyer, the book reveals how to scale not through policy, but through trust, talent density, and extreme transparency.

But this isn’t just about Netflix.

It’s about you—if you’re building or investing in companies between Series A and IPO, where culture either compounds performance or quietly kills it.

I walk you through 7 operational principles that deep-tech teams can apply now—lessons forged in crisis, growth, and reinvention. You’ll learn how to sunshine mistakes, pay like a pirate, and lead without becoming a bottleneck.

Each principle is translated into coaching prompts, ready to implement this week.

Key Takeaways:

• Culture Outruns Capital: Don’t optimize the engine—reinvent the vehicle.
• Pro Team > Family: Loyalty is earned through excellence, not tenure.
• Candor Drives Speed: Build feedback loops that fuel progress.
• Pay Top of Market: Buy peace of mind. Unlock creative flow.
• Bet Boldly: Seek dissent. Test. Learn. Repeat.
• Context Beats Control: Share the why. Let them own the how.
• Transparency = Trust: Open up, even when it’s uncomfortable.

Timestamps:

(00:00) Intro – Why Netflix Scaled Faster by Removing Rules, Not Adding Them
(04:30) Who Is Reed Hastings? – From Math Teacher to Global Disruptor
(09:13) Book Snapshot – What Makes No Rules Rules a Real Operating System
(11:35) Lesson 1: Culture Outruns Capital – How Netflix Survived 4 Disruptions, Blockbuster Didn’t Survive One
(17:25) Lesson 2: Build a Pro Team, Not a Family – Talent Density Over Loyalty
(22:48) Lesson 3: Radical Candor = Speed – The Feedback Model That Fuels Innovation
(27:34) Lesson 4: Pay Like a Pirate – Why Netflix Pays Top of Market—No Games, Just Outcomes
(32:20) Lesson 5: Bet Bold, Fail Proudly – The 4-Step Innovation Cycle That Keeps Netflix Ahead
(39:12) Lesson 6: Lead with Context, Not Control – Scaling Leadership Without Becoming a Bottleneck
(43:28) Lesson 7: Transparency Builds Velocity – How Truth-Telling Became Netflix’s Superpower
(48:15) 7 Key Takeaways – The Culture Playbook Every Growth-Stage Founder Needs
(50:15) Personal Reflection – What I Questioned, What I’ll Steal, What Gave Me Pause
(52:00) Call to Action + What’s Next – Support the Show + Tease of the Next Episode

Why Listen:

• Learn how Netflix scaled without micromanagement
• Get 7 principles that push your org design, talent strategy, and leadership edge
• Discover where you're still playing defense—when your culture should be your offense
• Upgrade your leadership thinking with real examples and immediate applications

Found this useful? Like, share, and follow.
Every signal grows the show—and brings in more elite guests ready to share the truths behind high-growth success.

🎙️ - Beginner's Mind. Top 10% global. #1 deep tech podcast. 200+ episodes.

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Most cancer drugs fail. Not because the science is wrong—because we’re solving the wrong problems.

The cost? Over $2 billion per failure. And for the patient waiting on a miracle—there’s no second chance.

Behind the headlines of “precision medicine,” there’s a deeper story nobody’s telling. Until now.

🎯 Enter Rafael Rosengarten, the scientist-turned-founder who’s rewriting the rules of drug development.

In this gripping conversation, we unpack how RNA, AI, and deep empathy could finally close the loop between biology, data, and the patient in the room.

🎧 Watch now to explore:
1️⃣ Why drug failure isn’t a tech problem—it’s a strategy problem
2️⃣ How “information companions” will guide every medicine to the right patient
3️⃣ What pharma keeps getting wrong about biomarkers—and how to fix it
4️⃣ The untold story behind turning down a chef’s job on a Mediterranean yacht
5️⃣ The real reason Genialis may one day go out of business (and why Rafael hopes it does)

👤 About Rafael Rosengarten
Rafael is CEO and co-founder of Genialis, the RNA biomarker company reshaping precision oncology. From academic labs to Michelin-star kitchens, his journey is anything but linear—but his mission is clear: make medicine make sense. With partners across pharma, diagnostics, and AI, Genialis is creating a world where every patient gets the treatment they actually need.

💬 Quotes That Might Shift Your Thinking:
(00:58:37) “Our AI biomarkers de-risk clinical trials, slashing costs and saving lives.”
(01:54:46) “Every drug will have an information companion guiding it to the right patient.”
(01:14:32) “AI should free humans for empathy and creativity, not replace them.”
(00:14:13) “We now have the tools to treat every cancer as unique to each patient.”
(01:31:38) “Stop selling technology; sell solutions to real problems.”

🧭 Timestamps to Explore:
(00:03:52) Inside the World’s Largest Medical Center
(00:10:30) How AI Is Rewiring Precision Medicine
(00:13:51) Why Precision Medicine Is Scaling Now
(00:17:34) Startups Must Solve Market Needs First
(00:23:53) Culture First, Then Business: Startup Blueprint
(00:27:57) Cancer Isn’t One Disease—It’s Thousands
(00:31:44) Predicting Drug Success with AI Biology
(00:36:40) Reimagining Biomarkers Using RNA and AI
(00:47:45) Why Early Detection Still Saves Lives
(00:57:30) Why Most Cancer Drugs Still Fail
(00:58:37) AI Biomarkers That De-Risk Clinical Trials
(01:09:42) Rethinking Dosage with Predictive Algorithms
(01:13:33) Why Human Intuition Still Matters in Science
(01:36:41) The Crystal Ball Question Pharma Can’t Ignore
(01:50:19) The moment where time disappears—and the real future begins.
(01:53:39) Every Drug Will Have an AI Companion

🔔 Let’s Rebuild Trust in Medicine—Together
If this episode sparked a new thought—or just gave you pause—don’t let it end here.

Subscribe. Share it with someone who still believes medicine can be both scientific and deeply human.

Every action brings in minds like Rafael’s… and gets us one step closer to treatments that truly heal.

🎧 Watch now—and discover how medicine gets smarter, safer, and more personal.

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Europe has the science. The talent. The breakthroughs.

But when an idea feels too uncertain, our systems shut it down before it has a chance to breathe.

And with every safe bet… we quietly lose the next cure, the next Car-T, the next AI that could change everything.

🚨 Risk-aversion, fragmentation, and bureaucracy are draining Europe’s innovation power—and nobody dares to name it out loud.

But Fabrizio Conicella, VP of Open Innovation at Chiesi Group, isn’t holding back.

💡 In this deep, urgent conversation, Fabrizio shares how Europe can build the ecosystems we need to turn bold ideas into real-world impact—without compromising ethics, patients, or long-term value.

🎧 Watch now to explore:
1️⃣ Why uncertainty, not risk, is the true frontier of innovation
2️⃣ The hidden reasons startups leave Europe—and how to keep them
3️⃣ How Chiesi’s “The Impulse” model flips corporate R&D on its head
4️⃣ What every policymaker, CEO, and scientist must change before it’s too late
5️⃣ A bold new playbook for turning visionary science into trusted medicine

👤 About Fabrizio Conicella:
As one of Europe’s leading voices in health innovation, Fabrizio is pioneering how pharma collaborates across startups, data, and ethics. His mission: create environments where the best ideas don’t get shut down—they get built.

💬 Quotes That Might Just Change Your Thinking:
(01:58:01) "Be bold enough to dream, but pragmatic enough to make it real."
(01:07:22) "Science is essential, but turning it into a product requires a different kind of wisdom."
(01:04:35) "Visionary entrepreneurs see the future and change the game."
(00:16:51) "Innovation today is no longer a race for ownership, but a journey of collaboration."
(00:47:55) "If the idea is truly bold, no pharma company can replicate it without you."

⏱️ Timestamps:
(03:00) Europe’s Innovation Crisis: A Wake-Up Call
(08:19) Chiesi’s Bold B Corp Strategy
(16:26) Building Healthcare Innovation Ecosystems
(22:09) Predictive Medicine and Patient Data
(29:49) Pharma vs. Startup Ecosystems Today
(34:38) Why R&D Must Go External
(35:06) The End of Buy-and-Wait Pharma
(41:42) Ethics First: Pharma’s New Mandate
(44:06) Respecting Founders, Not Just IP
(47:23) Debunking the 'Pharma Steals Ideas' Myth
(54:10) Why Pharma Moves Slowly—but Must Adapt
(59:25) Market Acumen: Startups’ Missing Ingredient
(01:04:35) What Makes a Visionary Entrepreneur
(01:29:22) Embracing Failure to Spark Innovation
(01:46:01) Europe’s Risk Culture is Holding Us Back

🔔 Help Us Grow the Future of Thoughtful Innovation
If this conversation sparked something in you—an insight, a question, a sense of urgency—help us keep it alive.
Subscribe. Leave a comment. Share it with someone who still believes bold ideas deserve a fighting chance.
Every action brings in deeper minds, bigger questions, and the kind of leadership our systems so desperately need.

Book mention: The Venture Mindset

🎧 Watch now—and join the movement to rebuild Europe’s innovation edge.

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What if the only way to save the planet... is to cool it?
Not figuratively—literally.
Because the heatwaves, floods, and fires you’ve seen so far? They’re just the beginning.

🌍 Emissions keep rising. Global cooperation is slowing. And the window to act is closing fast.
Now, world leaders are quietly weighing a radical idea: Should we artificially cool Earth before it’s too late?

💥 In this explosive episode, we dive into the most controversial climate strategy on the table today: solar radiation modification.

But who decides how much cooling is “enough”?
What happens if we act too late—or worse, too soon?

📌 In this episode, Janos Pasztor—former UN Assistant Secretary-General for Climate Change and climate advisor to Ban Ki-moon—breaks his silence on the plans world leaders are only now beginning to confront.

🎧 Watch now to uncover:

1️⃣ Why geoengineering may soon become a global necessity—not a fringe idea.
2️⃣ What governments aren’t telling you about unilateral climate interventions.
3️⃣ The ethical, political, and scientific minefield behind planetary cooling.
4️⃣ Why some scientists say this tech could save millions—and others call it madness.
5️⃣ What it will take to govern Earth’s thermostat before someone does it alone.

👤 About Janos Pasztor:
With nearly 50 years of experience in climate policy, diplomacy, and governance, Pasztor has shaped global climate strategy from inside the UN and beyond. From the 1992 Earth Summit to the corridors of the UN Security Council, he’s been advising heads of state on how to confront the world’s most complex crisis—and now, he’s sharing what’s coming next.

💡 Quotes to Challenge Your Thinking:
(00:08:41) “We must ask: is it time to start cooling parts of the planet?”

(01:21:07) “Stratospheric aerosol injection could cool the planet—yet we barely understand its consequences.”

(01:11:03) “The real question is whether capitalism can evolve beyond its dependence on resource extraction.”

(02:24:41) “Three degrees of warming is cuckoo land—it’s beyond what humanity can realistically adapt to.”

(02:47:03) “Climate policy isn't just climate—it’s about everything we do as a society.”

⏱️ Timestamps:
(00:04:12) Urgent Climate Crisis: Rising Emissions Explained
(00:10:15) Inconvenient Truth 2.0: What We Missed
(00:18:32) China’s Green Tech Revolution Unpacked
(00:26:20) Can Climate Forums Deliver Real Action?
(00:32:50) Designing Just, Achievable Climate Goals Globally
(00:40:06) How Growth Triggers Today’s Polycrisis
(00:45:08) Rethinking Economies for Sustainable Living
(00:53:00) Why We Need Mixed Energy Strategies
(01:17:24) Geoengineering vs Terraforming: Climate Futures Debate
(01:26:20) Who Funds Carbon Removal Technologies?
(01:37:06) Why We May Need to Cool Earth
(01:40:41) Warming Beyond 3°C: What’s at Risk
(01:48:02) How Fossil Fuels Hide True Heat
(02:08:00) The Hidden Risks of Cheap Climate Fixes
(02:24:41) 3 Degrees Warming: Scientifically Unmanageable?

🔔 Help Us Grow
If this conversation gave you insight, urgency, or a new perspective—help us keep it going.
Subscribe. Leave a comment. Share it with someone who cares.
Every single action helps us invite world-class thinkers, spark deeper debates, and bring you the conversations that actually matter.

🎧 Watch now—and be part of the climate conversation no one dares to start.

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What if your business ran like a well-designed machine—one that could evolve, self-correct, and outperform your competition over decades?

In this episode, I unpack Principles by Ray Dalio, the billionaire investor and founder of Bridgewater Associates, the world’s largest hedge fund. It’s not a traditional business book—it’s a blueprint for decision-making, culture design, and long-term scaling, rooted in clarity, transparency, and radical self-honesty.

This episode is built for venture capitalists, executives, and operators leading at scale—those who are no longer improvising but building enduring systems.

You’ll hear the 7 most actionable principles Dalio used to scale Bridgewater, reimagined for anyone building the future—from biotech to AI, from global funds to market-leading enterprises.

We cover how to engineer feedback cultures, design for evolution, and drive decisions that compound over time. And we tackle the big question: Can you be both a high-performance machine and a human-centered leader?

Key Takeaways:

1. Think Like a Machine: Build systems that run without your constant input.
2. Get the People Right: Talent isn’t enough—character and growth capacity matter most.
3. Radical Transparency: Trust is built by saying the hard things early and often.
4. Idea Meritocracy: Don’t default to consensus. Weight decisions by experience.
5. Shaper Thinking: Zoom out to vision, zoom in to execution—and toggle constantly.
6. Diagnose the Root Cause: Don’t waste time solving symptoms.
7. Open-Mindedness as Strategy: Challenge your thinking before reality does.

Timestamps:

(00:00) Intro: The Principles
(02:15) Why This Book Matters If You’re Building or Investing in the Future
(04:14) Who Is Ray Dalio?
(06:21) The Snapshot: What Principles Is Really About
(10:05) Build Your Company Like a Machine, Not a Hero’s Journey
(15:29) Get the People Right
(20:40) Radical Truth & Transparency Are Force Multipliers
(26:08) Build an Idea Meritocracy
(32:26) Shapers Win—They Dream Big, Think Clear, Execute Ruthlessly
(37:37) Diagnose Root Causes, Not Symptoms
(44:02) Be Radically Open-Minded
(50:12) Key Takeaways & Personal Reflection

Why Listen:

• Learn how billion-dollar systems are designed and scaled
• Identify blind spots in your leadership, org design, or investment theses
• Equip yourself with 7 operating principles you can implement this quarter
• Reframe your relationship to truth, conflict, and growth
• Decide whether to build a machine—or remain the operator

If these ideas resonate, I strongly recommend reading Principles in full. Or better yet—share this episode with someone you think is ready to level up how they lead and build.

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