Getting genuinely useful new technologies, from wearables to clinical decision support, into the clinic has proven to be surprisingly challenging. Tanzeem K. Choudhury, PhD, of Cornell Tech joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss how to take research into the real world in a way that is scalable and affordable.

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What hard lessons did the US Department of Veterans Affairs (VA) learn in 3 decades of EHR development, and what can it teach us about building better AI in medicine? Stephen Fihn, MD, MPH, of the University of Washington, and formerly a leader in the VA’s EHR efforts, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss his experience at the VA building decision support tools and other technology.

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European Society of Cardiology Vice President Carlos Aguiar, MD, discusses clinical research highlights from the largest scientific meeting in cardiovascular medicine, held recently in London. Updates include semaglutide findings, hypertension triple pills, and more.

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Quarraisha Abdool Karim, PhD, and Salim S. Abdool Karim, MBChB, PhD, are the recipients of the 2024 Lasker-Bloomberg Public Service Award for their decades of work on AIDS in Africa. The infectious diseases epidemiologists recently reflected on their life’s work in a conversation with JAMA Deputy Editor and infectious diseases physician Preeti Malani, MD, MSJ.

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Extreme heat and its health outcomes are becoming more common. Jeremy Hess, MD, MPH, an emergency medicine physician and professor at the University of Washington, and Andrew Phelps, former director of the Oregon Department of Emergency Management, join Jennifer Abbasi, director of JAMA Medical News, to discuss lessons learned from the unprecedented heat wave in June 2021.

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Here’s What to Know About the New Mpox Global Emergency; Controversial FDA Decision Authorizes Menthol-Flavored E-Cigarettes

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Sebastian Palmqvist, MD, PhD, and Wiesje van der Flier, PhD, cochairs of the 2024 Alzheimer’s Association International Conference, speak with JAMA Medical News Lead Senior Staff Writer Rita Rubin, MA, about highlights from the annual meeting, including a blood test for Alzheimer disease, repurposing of a GLP-1 receptor agonist, and the possible brain risk from inhaling wildfire smoke.

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• A Blood Test for Alzheimer Disease, Repurposing GLP-1s, and Wildfire Smoke—Highlights From the AAIC