Drs Jacob Sands and Benjamin Levy discuss the management of lung cancer with neoadjuvant and adjuvant therapy and the potential impact of current clinical trials.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969535). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Lung Adjuvant Cisplatin Evaluation: A Pooled Analysis by the LACE Collaborative Group https://ascopubs.org/doi/pdf/10.1200/JCO.2007.13.9030

ADAURA: Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer https://www.nejm.org/doi/full/10.1056/NEJMoa2027071

Osimertinib: Medscape Drugs & Diseases https://reference.medscape.com/drug/tagrisso-osimertinib-1000062

Adjuvant Atezolizumab After Adjuvant Chemotherapy in Resected Stage IB–IIIA Non-Small-Cell Lung Cancer (IMpower010): A Randomised, Multicentre, Open-Label, Phase 3 Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02098-5/fulltext

Atezolizumab: Medscape Drugs & Diseases https://reference.medscape.com/drug/tecentriq-atezolizumab-1000098

Pembrolizumab Versus Chemotherapy for Previously Untreated, PD-L1-Expressing, Locally Advanced or Metastatic Non-Small-Cell Lung Cancer (KEYNOTE-042): A Randomised, Open-Label, Controlled, Phase 3 Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32409-7/fulltext

Pembrolizumab: Medscape Drugs & Diseases https://reference.medscape.com/drug/keytruda-pembrolizumab-999962

Pembrolizumab (Pembro) Versus Placebo for Early-Stage Non-Small Cell Lung Cancer (NSCLC) Following Complete Resection and Adjuvant Chemotherapy (Chemo) When Indicated: Randomized, Triple-Blind, Phase III EORTC-1416-LCG/ETOP 8-15 – PEARLS/KEYNOTE-091 Study https://oncologypro.esmo.org/meeting-resources/esmo-virtual-plenary-resources/pearls-keynote-091-pembrolizumab-pembro-versus-placebo-for-early-stage-non-small-cell-lung-cancer-nsclc-following-complete-resection-and-adjuvant-chemotherapy

Neoadjuvant Nivolumab Plus Chemotherapy in Resectable Lung Cancer https://www.nejm.org/doi/10.1056/NEJMoa2202170

Nivolumab: Medscape Drugs & Diseases https://reference.medscape.com/drug/opdualag-nivolumab-relatlimab-4000249

Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non–Small-Cell Lung Cancer (NADIM phase II trial) https://ascopubs.org/doi/full/10.1200/JCO.21.02660

New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy (NADIM-ADJUVANT) https://clinicaltrials.gov/ct2/show/NCT04564157

Neoadjuvant Screening Trial: LCMC4 Evaluation of Actionable Drivers in EaRly Stage Lung Cancer https://www.lungcancerresearchfoundation.org/research/lung-cancer-mutation-consortium/current-lcmc-study/

ALCHEMIST: Adjuvant Targeted Therapy or Immunotherapy for High-Risk Resected NSCLC https://ascopubs.org/doi/10.1200/JCO.2020.38.15_suppl.TPS9077

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, ALCHEMIST Chemo-IO Study https://www.clinicaltrials.gov/ct2/show/NCT04267848