The Pet Longevity Lab – Episode: Neutering, Hormone Health & Librela: What Pet Owners Need to Know

In this episode of The Pet Longevity Lab, we dive into two critical topics reshaping veterinary medicine:

1️⃣ The long-term health challenges associated with routine spaying and neutering — including increased risks of joint disorders like hip dysplasia, cruciate ligament rupture, and even certain cancers. We explore how hormone replacement therapy (HRT), inspired by human studies, may offer a better path forward for our pets.

2️⃣ A deeper look at Librela (bedinvetmab), the popular anti-NGF drug used for canine osteoarthritis pain, and the alarming rise in musculoskeletal adverse events linked to its use. We break down recent data showing significantly higher rates of ligament injuries, fractures, and joint destruction in treated dogs — and why experts are raising the alarm.

From gaps in pharmacovigilance to the importance of hormone health, this episode pulls no punches in advocating for better, science-backed solutions for pet wellness.

Join us as we connect the dots between clinical data, pet owner concerns, and the future of proactive veterinary care.

1mpet.org for more information

In this episode, we explore the surprising and powerful link between testosterone and inflammation—and why this matters not just for humans, but for our pets too.

Drawing from peer-reviewed human studies by Mohamad et al. and Bianchi, we break down how testosterone influences pro-inflammatory cytokines, impacts adipose tissue, and plays a key role in chronic disease prevention. You’ll learn how low testosterone levels are associated with systemic inflammation and how hormone therapy in men has shown promising results in reducing markers like IL-6, TNF-α, and CRP.

So why are we talking about this on a pet health podcast?

Because pets—especially those that are spayed or neutered—also suffer from hormone deficiency and many of the same inflammation-driven conditions: arthritis, cognitive decline, obesity, and more. This episode lays the foundation for understanding how research in human endocrinology can guide integrative, evidence-based approaches to extending pet healthspan.

🔬 Key Topics Covered:

• Testosterone’s role in immune modulation

• The connection between fat tissue, inflammation, and hormone loss

• What the human data tells us about restoring balance in neutered/spayed pets

• Why this research is central to Pet Longevity Lab’s hormone-first philosophy

🎧 If you care about science-backed pet wellness, aging, and inflammation—this episode is a must-listen.

👉 Learn more at 1mpet.org

In this episode of The Pet Longevity Lab Podcast, we explore the latest research linking testosterone, osteoarthritis, and joint health in both women and companion dogs. A recent study suggests higher testosterone levels may protect women from knee OA, while another large-scale study in dogs identifies neutering and weight gain as major OA risk factors—raising critical questions about the role of sex hormones in joint health.

Join us as we break down the science, risks, and practical takeaways for both human and veterinary medicine. Could hormone balance be the key to longevity and mobility? Tune in to find out!