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  • TWiV 1153: Viruses that (can) make you well

    TWiV 1153: Viruses that (can) make you well
    2024/09/29

    From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections.

    Hosts: Vincent Racaniello and Jolene Ramsey

    Guests: Krystyna Dabrowska and Rob Lavigne

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Viruses of Microbes 2024
    • Immune responses to phages (Front Immunol)
    • Engineering bacteriolytic enzymes (Front Immunol)
    • 100 cases of phage therapy (Nat Micro)
    • Synthetic biology potential of bacteriophages (Nat Micro)
    • Timestamps by Jolene. Thanks!

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    55 分
  • TWiV 1152: Clinical update with Dr. Daniel Griffin

    TWiV 1152: Clinical update with Dr. Daniel Griffin
    2024/09/28
    In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Waning vaccine protection against mpox…..isn’t this the way the humoral immune response works? (CIDRAP)Uncontrollable mpox outbreak in Africa (Reuters)Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv)Mpox vaccine for adolescents approved (Pharmaceutical Technology) Clade 1b mpox visiting India (CIDRAP) Mpox clade 1b in Kerala (ANI South Asia’s Leading Multimedia News Agency)US government orders $63M worth of small pox/mpox vaccine (Reuters)Mpox donations boosting global supply (US Department of Health and Human Services)I million mpox vaccine doses for Africa….with love from US government (CIDRAP) Speed doses of mpox vaccine (CIDRAP)Mpox vaccine donations (UNICEF) Bavarian Nordic mpox vaccine (Yahoo finances)Early epicenter of COVID-19 pandemic Huanan seafood market (Science)Wildlife trade likely source of SARS-CoV-2 (Science)Zoonotic origins of SARS-CoV-2 (Science)Surveillance at the Huanan Seafood market (Europe PMC)TWiV shout outs…..all for the SARS-CoV-2 spill over from nature TWiV 1019: Eddie Holmes on SARS-CoV-2 originsTWiV 1017: From Nature, not a labTWiV 995: Viral origin storiesTWiV 940: Eddie Holmes in on viral originsTWiV 876: Spillover market with Michael WorobeyTWiV 762: SARS-CoV-2 origins with Robert GarryTWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion KoopmansTWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences Genetic tracking of market wildlife and viruses at Huanan Market (Cell)Combatting scientific misinformation (microbeTV: TWiV)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Suggestion for the use of a new preventive COVID-19 agent (IDSA) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Lower mortality risk associated with remdesivir + dexamethasone versus dexamethasone for hospitalized COVID-19 patients (CID)Changes in memory and cognition during the SARS-CoV-2 human challenge study(eClinical Medicine)Letters read on TWiV 1152Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    58 分
  • TWiV 1151: Hotel California for Phage

    TWiV 1151: Hotel California for Phage
    2024/09/22

    TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly.

    Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Polio vaccination in Gaza (Reuters)
    • Zoonotic viruses in farmed fur animals (Nature)
    • HPV vaccination and cancer rates (JAMA Net Open)
    • 40 kb RNA genome without error correction (PNAS)
    • Stopping the phage tape measure protein (Nat Commun)
    • Tail assembly interference (Nat Commun)
    • Letters read on TWiV 1151
    • Timestamps by Jolene. Thanks!
    Weekly Picks

    Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year
    Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors
    Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum
    Vincent – The collapse of bat populations led to more than a thousand infant deaths

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 時間 44 分
  • TWiV 1150: Clinical update with Dr. Daniel Griffin

    TWiV 1150: Clinical update with Dr. Daniel Griffin
    2024/09/21
    In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower incidences of long COVID. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode West Nile virus in New Jersey (CBSNews)Poliovirus vaccination 90% coverate (Reuters) Suspension of poliovirus eradication by the Taliban (apnews)California dengue cluster (CIDRAP) Children dying of influenza (CIDRAP) 199 children deaths from flu (CDC) Bavarian Nordic mpox vaccine (Yahoo finances) Prequalification of MVA-BN mpox vaccine (WHO Int) Speed doses of mpox vaccine (CIDRAP)GAVI rapidly secures 500K doses of mpox vaccines for Africa(GAVI)Expanded access to teconvirimat for mpox treatment in US 2022-2023(NEJM Evidence) FluView (CDC) Human to human transmission of bird flu in Missouri? (NY Times)Bird flu isolated from humans in Missouri similar to that found in cattle (CNN)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)Waste water scan for 11 pathogens (WastewaterSCan)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage (CID)Early, robust mucosal secretory IgA but not IgG response to SARS-CoV-2 spike in oral fluid is associated with faster viral clearance and COVID-19 symptom resolution (JID)Suggestion for the use of a new preventive COVID-19 agent (IDSA) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Lierpool)Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Metformin use in adults with diabetes and incidence of long COVID (Diabetes Care)Letters read on TWiV 1150Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    48 分
  • TWiV 1149: Mary Estes, a gutsy virologist

    TWiV 1149: Mary Estes, a gutsy virologist
    2024/09/15

    From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus.

    Hosts: Kathy Spindler and Brianne Barker

    Guest: Mary Estes

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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    Links for this episode
    • MicrobeTV Discord Server
    • Diarrhea induced by rotavirus NSP4 (Science)
    • Minimal infective dose of rotavirus (Arch Virol)
    • mRNA release from rotavirus particles (Nat Struct Biol)
    • Norovirus vaccine (Clin Ther)
    • Timestamps by Jolene. Thanks!

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 時間 5 分
  • TWiV 1148: Clinical update with Dr. Daniel Griffin

    TWiV 1148: Clinical update with Dr. Daniel Griffin
    2024/09/14
    In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lending you the viruses in my fur (Nature) mRNA or vaccinia based mpox vaccine (Cell)Virtual outpatient management of mpox (OFID)NYC: mpox vaccination finder (NYC)Vaccine, mpox/COVID-19 near you (NYC)Expensive or not expensive anti-RSV monoclonal therapy for infants (American Academy of Pediatrics)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Association of vaccination and SARS-CoV-2 viral load phase 3 (JID) IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)Early phase of SARs-CoV-2 infection (COVID.gov) CDC Quarantine guidelines (CDC)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Long COVID following infection with Omicron: oral microbiota changes(American Journal of Medicine)Letters read on TWiV 1148Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    45 分
  • TWiV 1147: Breastmilk paradox for norovirus

    TWiV 1147: Breastmilk paradox for norovirus
    2024/09/08

    TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea.

    Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

    Become a patron of TWiV!

    Links for this episode
    • MicrobeTV Discord Server
    • Multi-country Mpox outbreak (WHO)
    • Face covering ban in Nassau County (NBC)
    • Polio case in India (Business Standard)
    • More acceptance of vaccine misinformation (EurekAlert)
    • War in Gaza not just causing polio (Jerusalem Post)
    • Scientist run virus genome database (Science)
    • Mpox epidemiology and vaccine effectiveness (Emerg Inf Dis)
    • Newborn vulnerability to norovirus diarrhea (Cell Host Microbe)
    • Timestamps by Jolene. Thanks!
    Weekly Picks

    Brianne – Viral adaptation to climate change
    Rich – “Understanding the biology of monkeypox virus to prevent future outbreaks” by B. Moss
    Vincent – We can now watch Grace Hopper’s famed 1982 lecture on YouTube

    Intro music is by Ronald Jenkees

    Send your virology questions and comments to twiv@microbe.tv

    Content in this podcast should not be construed as medical advice.
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    1 時間 46 分
  • TWiV 1146: Clinical update with Dr. Daniel Griffin

    TWiV 1146: Clinical update with Dr. Daniel Griffin
    2024/09/07
    In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Recommendations for seasonal influenza prevention and vaccines (MMWR)Gaza: poliovirus RNA in sewage water (Reuters)Success of the polio vaccination campaign in Gaza (Reuters) UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi)mpox vaccine tender (CIDRAP)What about vaccines? (Bavarian Nordic)Resolving food insecurity (UNICEF USA)Semaglutide and the SELECT trial(Journal of the American College of Cardiology)COVID-19 deaths (CDC)COVID-19 national and regional trends (CDC)COVID-19 variant tracker (CDC)SARS-CoV-2 genomes galore (Nextstrain)Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC)Early phase of SARs-CoV-2 infection (COVID.gov)NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society)Drug interaction checker (University of Liverpool)Molnupiravir safety and efficacy (JMV)Convalescent plasma recommendation for immunocompromised (ID Society)What to do when sick with a respiratory virus (CDC)When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)Managing healthcare staffing shortages (CDC)Optimal duration of systemic corticosteroids treatment (OFID)Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org)Does vaccination prevent long COVID (LANCET: Respiratory Medicine)Fibrin drives thromboinflammation & neuropathology in COVID-19(Nature)Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)Letters read on TWiV 1146Dr. Griffin’s COVID treatment summary (pdf)Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
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    38 分