• Tools & Techniques for the Study of Biologics & Antibody Drug Conjugates

  • 2024/10/07
  • 再生時間： 48 分
  • ポッドキャスト

Tools & Techniques for the Study of Biologics & Antibody Drug Conjugates

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  • The fundamental cellular mechanisms of internalization and trafficking are crucial to many areas of cell biology, especially the proper function of therapeutic antibodies.

    Antibodies intended for use as antibody-drug conjugates (ADCs) should specifically bind to target cells and rapidly internalize via endocytosis.
    However, the ability to study these processes has historically been limited by the lack of tools that directly monitor the internalization and subsequent catabolism of extracellular material.

    In this episode, get a demo of rapid, high-throughput methods to screen for antibody internalization. You will also hear about techniques to directly visualize the internalization of therapeutic antibodies and ADCs in live cells for structure-activity relationship studies.

    You will also learn how the insights provided by these approaches have the potential to accelerate biotherapeutic lead generation and development.

    Watch the full presentation here: https://events.bitesizebio.com/tools-techniques-for-the-study-of/join

    Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/
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あらすじ・解説

The fundamental cellular mechanisms of internalization and trafficking are crucial to many areas of cell biology, especially the proper function of therapeutic antibodies.

Antibodies intended for use as antibody-drug conjugates (ADCs) should specifically bind to target cells and rapidly internalize via endocytosis.
However, the ability to study these processes has historically been limited by the lack of tools that directly monitor the internalization and subsequent catabolism of extracellular material.

In this episode, get a demo of rapid, high-throughput methods to screen for antibody internalization. You will also hear about techniques to directly visualize the internalization of therapeutic antibodies and ADCs in live cells for structure-activity relationship studies.

You will also learn how the insights provided by these approaches have the potential to accelerate biotherapeutic lead generation and development.

Watch the full presentation here: https://events.bitesizebio.com/tools-techniques-for-the-study-of/join

Browse all episodes of the Listen In Series here: https://listen-in.bitesizebio.com/
続きを読む 一部表示

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