In this episode of the Venture Capital Podcast, host Peter Harris sits down with Rex Salisbury, solo GP of Cambrian and former fintech partner at Andreessen Horowitz, for an in-depth conversation about the ongoing transformation of financial services. Rex shares his unique journey from investment banking to leading one of fintech’s most dynamic pre-seed and seed funds, explaining how decades of inefficiency in banking have finally given way to a wave of disruptive innovation.

The discussion explores recent shifts in the fintech landscape, highlighting how new fintech companies, once dismissed as serving only niche or low-value customers, are now directly competing with and winning market share from the largest legacy banks. Rex points to the rise of digital-first platforms like Robinhood and Wealthfront, which started by serving overlooked users but have evolved into sophisticated competitors for the millennial and Gen Z wealth transfer.

Peter and Rex examine why B2B fintech is an especially powerful force, with vertical software companies like Toast integrating lending, payroll, and banking into a single platform that businesses can’t imagine leaving for traditional banks. Rex also tackles the myth of banks’ cost-of-capital advantage, arguing that technology and changing consumer expectations are steadily eroding long-held bank moats.

Beyond consumer trends, the episode ventures into the investment landscape, with Rex sharing lessons from recent Cambrian investments, such as companies revolutionizing transfer agents and simplifying business shutdowns. The conversation also addresses the role of crypto and stablecoins in reshaping payment and banking infrastructure, where Rex differentiates between international and U.S. use cases but remains optimistic about crypto’s role as a catalyst for industry change.

Rex closes with actionable advice for aspiring founders and operators: seek out dense talent networks, work in growth-stage companies, and always surround yourself with people who teach you. The episode captures the underlying message that, as technology, business models, and capital flows shift, fintech is only just beginning to threaten incumbents and capture its share of the financial future.

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In this thought-provoking episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris explore the rapid evolution of artificial intelligence and its far-reaching implications for economics, labor, and opportunities. The conversation opens with Peter reflecting on his 16 years of VC experience and the unprecedented speed at which generative AI is impacting every industry, likening the current era to previous technological shifts such as the rise of the internet, mobile, and SaaS, but at a much more accelerated, all-encompassing pace.

Jon shares candid anxieties and perspectives from the founder’s side, debating whether society is overestimating the short-term disruption of AI while underestimating its long-term impact. The hosts explore parallels between AI’s rise and earlier workforce interventions, such as calculators and spreadsheets, suggesting that while some jobs will evolve or disappear, new types of roles and vast opportunities will emerge.

They debate the looming questions around AGI, the shifting utility of STEM degrees, and the growing importance of learning how to think critically and adapt. The discussion delves into:

• The shifting economics of labor versus capital as AI and robotics automate more tasks.
• The likely deflationary impact of AI, how costs may decline, and whether wages will keep pace.
• The paradox of abundance: more possibilities than ever, but also greater competition and the necessity for specialization.
• The challenge of retraining, critical thinking, and the risk of over-reliance on AI as a cognitive crutch.
• Wealth concentration, potential social upheaval, and whether universal basic income or new types of jobs will take hold.
• Unique advantages in interpersonal and relationship-driven sectors, and how VCs and founders might sustain an edge in an automated world.

The episode concludes with tangible advice for the next generation: develop deep, critical, interdisciplinary knowledge and be prepared to leverage rather than be replaced by AI. Jon and Peter encourage listeners to reflect on how they’ll stay relevant, creative, and entrepreneurial in a world where opportunity and risk are amplifying in tandem. This episode is essential listening for anyone curious about the future of work, education, and value creation in an AI-driven era.

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In this episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris reflect on key lessons from recent interviews with entrepreneurs, medical innovators, and content creators, turning their focus inward for a wide-ranging discussion on the evolving role of influencers, authenticity, and attention in today’s business world.

Jon and Peter kick off by revisiting the intersection of health technology and consumer empowerment, discussing the surge in wearables, at-home diagnostics, and consumer-led health journeys. They probe why younger generations are more invested in their health, attributing this trend to social visibility, the desire for authenticity in a digital age, and the rapid acceptance of medical advances, such as GLP-1 treatments for weight loss.

The conversation shifts dynamically to the creator economy, exploring how the most effective marketing and brand-building today often comes from content creators and influencers with passionate, loyal audiences. Peter highlights the unique value these creators bring, citing the example of a tech startup that attributes much of its rapid growth to a co-founder’s expertise in cultivating online engagement, rather than traditional marketing.

Jon and Peter debate whether every CEO now needs to be a content creator and ponder the future of influencer-led businesses. They analyze the success of influencer-driven brands like Hailey Bieber’s, dissecting how authentic involvement can drive enormous margins and corporate valuation, while also questioning the long-term challenges when founders sell to larger corporations.

They conclude with practical insights for founders: thoughtfully consider influencer involvement as part of founding teams, seek authenticity over mere endorsements, and recognize that in a noisy digital world, capturing and sustaining attention may be the single most valuable asset for any business.

This episode offers a forward-looking perspective on how authenticity, strategic influencer partnerships, and the ability to cut through digital noise are reshaping not just marketing but the very foundations of building and scaling a modern brand.

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In this forward-thinking episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris are joined by two leaders shaping the future of healthcare: Ryan Morley, Partner at Springside, and Dr. Jon Lensing, co-founder and CEO of Open Loop. Together, they dive deep into the rapidly evolving landscape of telehealth and digital health, exploring how technology, AI, and new business models are transforming care delivery.

Dr. Lensing shares his journey from rural medicine to building Open Loop, a telehealth infrastructure company designed to bring healthcare directly to where people live, work, and play. He explains how Open Loop is enabling non-traditional platforms—like gyms, dating apps, and retail stores—to offer convenient, on-demand healthcare services, fundamentally shifting care from hospitals and clinics to everyday environments.

Ryan Morley and Peter Harris discuss the investment opportunities emerging from this shift, highlighting how the COVID-19 pandemic accelerated telehealth adoption and how the next wave of innovation will focus on infrastructure, personalization, and value-based care. The conversation explores the power of AI in healthcare, from automating clinical documentation and patient intake to improving diagnoses and care coordination. Dr. Lensing details how Open Loop leverages AI to drastically reduce clinician workload and enhance patient engagement, while Ryan emphasizes the need for regulatory evolution to unlock the full potential of autonomous and AI-driven care.

The group also examines the broader determinants of health, noting that 85% of health outcomes are tied to lifestyle and environment rather than traditional medical care. They discuss how digital health can proactively address chronic disease, expand access, and empower consumers to take charge of their well-being.

Packed with insights on infrastructure, investment trends, regulatory hurdles, and the promise of AI, this episode is a must-listen for founders, investors, and anyone interested in the future of healthcare.

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In this dynamic episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris are joined by Tim Holladay, investor and co-founder of Space Station Investments, and Peter Hollens, renowned vocalist and innovative content creator. Together, they explore the evolving intersection of content creation, AI, and investment in the digital age.

The conversation kicks off with Peter Hollens sharing his unique perspective as both a world-class musician and a forward-thinking entrepreneur deeply engaged with AI’s impact on creativity. Tim Holladay highlights their collaborative investment approach, focusing on early-stage consumer companies and the growing role of creators in startup ecosystems.

Jon and Peter dive into the challenges and opportunities AI presents for content creators, from accelerating production to the flood of AI-generated content saturating digital platforms. Peter Hollens discusses how authentic human connection and parasocial relationships remain invaluable even as AI blurs the lines between human and machine-generated content. He shares fascinating examples of using AI tools to enhance creativity and even assist his autistic child, illustrating AI’s potential beyond entertainment.

The episode also tackles the evolving landscape of influencer marketing, the value creators bring as low-cost, high-ROI partners, and the shifting dynamics between brands and digital creators versus traditional influencers. The hosts and guests debate how AI-driven content might reshape attention economies, audience engagement, and the future of long-form versus short-form content.

Throughout the lively discussion, Peter Hollens recounts his challenging experience addressing AI skepticism at a recent commencement speech, underscoring the cultural divide around AI adoption. Tim and the hosts reflect on how investors and creators alike must embrace AI tools to stay ahead in a rapidly changing environment.

This episode offers a rich, nuanced exploration of how AI is transforming content creation, investment, and the creator economy, providing valuable insights for founders, investors, creators, and anyone curious about the future of digital media.

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In this insightful episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris are joined by Max Marchione, CEO and co-founder of Superpower.com, and Dr. John Dayton, MD, MBA, a healthcare innovator and venture partner. Together, they explore the evolving landscape of health technology and data intelligence, focusing on how cutting-edge biomarker analysis and AI-driven insights are reshaping disease prevention and personalized care.

Max shares his vision of building a healthcare system centered on enhancing human capability and longevity, emphasizing the shift from reactive treatment to proactive prevention. Dr. Dayton brings his frontline experience as an emergency physician and Stanford faculty member to discuss the current challenges in healthcare, including fragmented data systems and the need for interoperability to enable comprehensive, predictive care.

The conversation dives deep into the limitations of traditional single biomarker approaches and the promise of aggregating multiple data points into comprehensive health scores, like the Superpower Score. They discuss the critical role of omics data, continuous wearable monitoring, and multimodal AI in advancing personalized medicine. Dr. Dayton highlights the importance of integrating clinical data with remote patient monitoring to improve patient outcomes and reduce hospitalizations.

Throughout the episode, the guests and hosts examine the barriers to adopting these innovations within existing healthcare reimbursement models and the potential for value-based care to drive systemic change. This episode offers a forward-thinking perspective on how technology, data, and innovation converge to create a more effective, patient-centered healthcare future.

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In this episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris analyze how recent government policy shifts and economic changes are influencing the venture capital landscape and broader economy. They discuss the effects of tariffs, government spending, and regulatory uncertainty on startups and investors, highlighting concerns from founders and VCs alike about how these factors impact funding availability and business operations.

Jon and Peter explore the challenges faced by companies reliant on government contracts and grants, noting how freezes and delays can threaten runway and survival. They also examine the broader fiscal picture, including rising national debt, the potential consequences of inflation and tax hikes, and the complex balancing act governments face in cutting spending without triggering recession.

The conversation touches on real-world examples, such as illustrating how radical change can sometimes be necessary to drive growth amid adversity. The hosts debate the need for significant budget cuts versus gradual reductions and discuss the antiquated state of government technology and defense spending, considering opportunities for modernization and efficiency.

Finally, Jon and Peter share their predictions for the year ahead, weighing the short-term impacts of tariffs and the likelihood of economic downturns against the resilience of the market and potential for innovation. This episode offers a nuanced perspective on how government actions ripple through the venture capital ecosystem and what founders and investors can expect in a shifting economic environment.

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In this episode of the Venture Capital Podcast, hosts Jon Bradshaw and Peter Harris dive into one of the most critical yet often overlooked topics for startup founders: the questions you should be asking venture capitalists before taking their money. Drawing on their extensive experience, Jon and Peter discuss common pitfalls that founders face when negotiating deals, including the hidden terms in contracts that can come back to haunt a company years later.

The hosts stress the importance of doing deep due diligence on potential investors—not just their financial terms, but their character and how they handle failure. They emphasize asking tough questions about how a VC firm supports struggling portfolio companies and their philosophy on valuation and terms. Jon and Peter also reflect on the delicate balance founders must strike in pushing back while maintaining a constructive relationship.

Listeners will gain valuable insight into the realities of venture capital beyond the pitch room—the importance of understanding who is investing in your company, how VCs behave when things go wrong, and how to spot red flags early. This episode is an essential guide for founders preparing to raise capital and aiming to build a strong, lasting partnership with investors.

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