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In this issue: "10 Breakthrough Technologies of 2015: Where Are They Now?" by Tom Simonite; "5 Robot Trends to Watch for in 2016" by Will Knight; "What Will It Take to Build a Virtuous AI?" by Will Knight; "What Robots and AI Learned in 2015" by Will Knight; "The 6 Most Important Things That Happened in Virtual Reality in 2015" by Rachel Metz; "Human-Animal Chimeras Are Gestating on U.S. Research Farms" by Antonio Regalado; "Parents Turn to Prozac to Treat Down Syndrome" by Bonnie Rochman; "2015 in Biomedicine: Baby Engineering, Spray-On GMOs, and Cancer Cures" by Antonio Regalado.

In this issue, you’ll learn why Silicon Valley has never been successfully reproduced. You’ll hear the secret to becoming the next tech hot spot. You’ll learn how Beijing is being turned into a technology powerhouse….

You’ll learn how local programmers and homegrown business models are helping to realize the vast promise of using phones to improve health care and save lives. You’ll hear how an Internet pioneer’s quest to quantify everything about his health led him to a startling discovery. You’ll learn how personalized cancer treatment may have finally arrived. You’ll hear how a startup is trying to reinvent computer networking in an effort to make Internet services smarter, faster, and cheaper.

You’ll learn how Facebook is pushing beyond data-driven studies on voting, sharing, and organ-donation prompts, to make people feel good or bad. You’ll hear how inventor and futurist Ray Kurzweil is working with Google to apply his theory of intelligence to understanding online information. You’ll learn how Amazon’s Fire Phone could make visual search easier, better, and more popular. You’ll hear how IBM is working on a new computer chip – which could be up to five times faster than current transistors. You’ll learn how smart homes will require unprecedented effort to ensure not just security but also usability. And you’ll hear news from the worlds of Biomedicine, Technology and Communications.

You’ll learn how New York is investing in financial startups to make sure technologists and new ideas stick around. You’ll hear how mobile carriers are turning to sophisticated data analytics in order to give better service to high-paying customers. You’ll learn how some of the leading mobile carriers are joining forces in an effort to compete with Google in the mobile payment business. You’ll hear why a college dropout with no background in finance is meetings with some of the world's biggest banks.

In this issue, learn why we are having difficulties solving the big problems. You’ll learn about United States’ plan of sending astronauts to Mars in 2030. You’ll hear about the looming Alzheimer's health-care disaster. You’ll learn whether online colleges are just a fad or the change that higher education needs. And you’ll learn how solar-powered microgrids could help bring power to millions of the World’s poorest.

In this issue, you'll hear how social media, Wi-Fi gadgets and a sense of shame keep people motivated. You'll learn why an alliance with Facebook should give Microsoft an edge against search rival Google. You'll hear why some of the world's biggest technology companies have on-demand video on their slate for the upcoming year. You'll learn about a new device that can scan fingerprints from up to two meters away.

In this issue, you’ll learn what China’s next great economic advantage could be. You'll hear how Facebook emerged from a privacy scandal to become online advertising’s next great hope. You’ll learn how demonstrating IBM’s software on Jeopardy! may have been a bad idea. You’ll hear why it may be a good idea to start taking price into account when considering approval or coverage of new drug treatments.

In this issue: "35 Innovators Under 35 2015" by The Editors of Technology Review. "The Next Great GMO Debate" by Antonio Regaldo.

You’ll learn about the TR10, the 10 most important technological milestones reached in the last 12 months. You’ll hear about the tribulations involved in creating a public repository of every book ever published. You’ll learn how social communications played a big part on the war against Qaddafi. And you’ll find out why Apple’s iPhone app, Siri works so well.

In this issue: 10 Breakthrough Technologies 2016: "Immune Engineering" by Antonio Regalado. "Precise Gene Editing in Plants" by David Talbot. "Conversational Interfaces" by Will Knight. "Reusable Rockets" by Brian Bergstein. "Robots That Teach Each Other" by Amanda Schaffer. "DNA App Store" by Antonio Regalado. "SolarCity's Gigafactory" by Richard Martin. "Slack" by Lee Gomes. "Tesla Autopilot" by Ryan Bradley. "Power from the Air" by Mark Harris. Also: "Should Silicon Valley Go to War?" by Fred Kaplan. "Apprentice Work" by Martin Gayford.

For our 13th annual celebration of people who are driving the next generation of technological breakthroughs, we’re presenting the stories in a new way. We’ve grouped them by categories that reflect the variety of approaches that people can take to big problems. First we introduce you to Inventors, who are creating new technologies. Next come Entrepreneurs, who are turning technologies into viable businesses. Then meet the Visionaries, who are anticipating how technologies can make life better, while Humanitarians are concentrating on expanding opportunities. Finally, the Pioneers are exploring new frontiers, setting the stage for future innovations.

In this Special Issue, Technology Review’s 35 Innovators Under 35. All 35 of these people are doing exciting work that could shape their fields for decades. But they’re solving problems in remarkably different ways. We consider some of them to be primarily Inventors; they’re immersed in building new technologies. Others we call Visionaries, because they’re showing how technologies could be put to new or better uses. Humanitarians are using technology to expand opportunities or inform public policy. Pioneers are doing fundamental work that will spawn future innovations; such breakthroughs will be taken up by tomorrow’s Entrepreneurs, people who are building new tech businesses. Everyone on the list was nominated either by the public or by MIT Technology Review’s editors. Some got our attention when they were picked by our international publishing partners as Innovators Under 35 for their regions. After our editors pared the roughly 500 nominees to 80 finalists, outside judges rated the originality and impact, or potential impact, of their work; those scores guided the editors as they crafted the list.

In this issue: "Microsoft's Top Lawyer Becomes a Civil Rights Crusader" by Tom Simonite; "Bill Gates Doubles His Bet on Wiping Out Mosquitoes with Gene Editing" by Antonio Regalado; "Manufacturing Dopamine in the Brain with Gene Therapy" by Antonio Regalado; "China's Headlong Rush into an Ultra-expensive Cancer Therapy" by Yiting Sun; "Fetal Cells Offer Promise in Prenatal Testing" by Bonnie Rochman; "A Big Step Forward in the Quest for a Better Painkiller" by Adam Piore; "Life as an Entrepreneur in a Violent Mexico" by Adam Popescu.

Welcome to Technology Review’s Special Edition for September 2012 on the 35 Innovators Under the Age of 35. Some members of our latest list of young innovators from around the world have developed consumer Web services you might have used, such as Spotify or Dropbox. Others are making more fundamental breakthroughs that have yet to be commercialized, such as more efficient engines or improvements in optical communications. And a few are blazing trails in fields that didn’t exist before, like pop-up fabrication of tiny machines, or cameras that can see around corners. But all 35 of them have something significant in common: their work is likely to be influential for a very long time. We hope that these stories about them surprise and inspire you.

In this issue, you’ll learn how Artificial intelligence is finally getting smart. You’ll hear about the next frontier of the genome revolution. You’ll learn about a maverick neuroscientist who believes he has deciphered the code by which the brain forms long-term memories. You’ll hear about the debate over what our responsibilities and duties are to help safeguard the distant future from global warming. And you’ll learn why we need technology that enhances human drivers’ abilities rather than making those abilities increasingly obsolete.

In this issue, you'll hear how wireless carriers are working hard to improve the network - so they can meet the demanding needs of their growing customer base. You'll learn about the Que [Q], Plastic Logics thin, lightweight e-reader based on organic transistors. You'll hear how companies are working on ways to combine social networking with TV viewing. You'll learn how Google has adapted its technology in order to keep search returns relevant.

In this issue: "Procuring Innovation" by Fred Kaplan; "The Hole in the Digital Economy" by David Talbot; "Rejuvenating the Chance of Motherhood?" by Karen Weintraub; "The Cancer Lottery" by Stephen S. Hall; and "Google's Long, Strange Life Span Trip" by Antonio Regalado.

In this issue, you’ll learn how new devices that monitor activity, sleep, diet, and even mood, could make us healthier and more productive. You'll hear how crooks peddling fake antivirus software have duped the Web in a billion-dollar rip-off. You’ll learn about a stem-cell treatment that holds out hope to people who are paralyzed. You’ll hear how the former CTO of Microsoft is trying to transform the way we eat.

There’s more than one way to read these stories. Sure, the subjects are inspiring and creative people. But these are not merely personality profiles.