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In this episode of The Uprising Show, host Vivek sits down with Manush Saydmohammed, Ph.D., MBA, co-founder and CEO of ZEGENEX Inc., a Pittsburgh-based startup developing innovative wound healing solutions. Manush shares his remarkable journey from humble beginnings in Kerala, India, through a career in biomedical research across India, Japan, and the US, to becoming an entrepreneur driven by the desire to translate cutting-edge science into real-world medical solutions.

The conversation dives into how the COVID-19 pandemic inspired Manush to transition from academic research to the world of startups, and explores the science behind ZEGENEX’s groundbreaking small-molecule cream designed to accelerate healing in chronic wounds like diabetic foot ulcers. Manush candidly discusses the challenges of moving novel therapies from the lab to the clinic, the importance of patents and collaboration, and the regulatory hurdles unique to new drug entities.

They also touch on the exciting future of health tech, from AI-accelerated drug discovery to gene editing and personalized medicine. Manush closes by sharing personal insights on entrepreneurship, including the importance of mindset, adaptability, and the inspiration he draws from innovators like Mark Cuban. Whether you’re passionate about science, startups, or healthcare innovation, this episode offers an inspiring look into the entrepreneurial journey and the potential to make a real impact in patient care.

Timestamps:

00:00 From Kerala to the US: Research Journey

04:24 Navigating Transitional Unlearning

07:08 Pioneering Treatment for Chronic Wounds

11:44 Product Success: Feasibility and Viability

16:04 Zebrafish: Ideal Heart Regeneration Model

19:45 Patents Ensure Product Credibility

22:43 New Drug Device Regulatory Pathway

26:46 AI in Drug Discovery

30:27 Stem Cell Industry Exploration

31:33 Diabetic Foot Ulcer Study Phases

36:50 Change Habits, Mark Cuban Inspiration

38:30 "Challenging Fundraising, Hopeful Future"

The Uprising Show Website: https://theuprisingshow.com/

Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/

Vivek Nanda's Twitter: https://x.com/vickks

TopHealth Media Website: https://tophealth.care/

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Welcome back! In this episode, we sit down with Scott Chetham, CEO and co-founder of Faro Health, for an in-depth conversation about revolutionizing clinical trials with data-driven technology. Scott shares his unexpected journey from Australia’s Gold Coast to becoming a healthcare tech leader in San Diego, and how his upbringing, shaped by his parents’ perseverance and partnership, inspired his approach to entrepreneurship.

In this conversation, Scott digs into the complexities of clinical trial design and the inefficiencies plaguing the industry, especially the over-reliance on outdated tools like Microsoft Word. Discover how Faro Health is modernizing the way trials are designed and managed, harnessing AI and automation to reduce costs, accelerate timelines, and improve patient experiences. Scott offers candid insights into the real problems facing pharma companies and hospital systems today and provides a behind-the-scenes look at building an innovative SaaS business in such a highly regulated space.

Whether you’re curious about the future of drug development, the role of generative AI in healthcare, or what it really takes to build a company that is changing the status quo, this episode is packed with personal stories, expert opinions, and actionable takeaways. Plus, you’ll learn why Scott’s not likely to talk cricket—despite his Aussie roots.

Tune in for an episode that’s both thought-provoking and genuinely inspiring!

Timestamps:

00:00 "Legacy of Freedom and Surprise"

05:19 Trailblazing Career and Educational Impact

06:44 Cardiac Electrophysiology Journey

13:12 "Complexity's Role in Trial Failure"

14:09 Streamlining Vaccine Design with Data

20:07 Accelerating Genome Editing Processes

22:10 Trial Data Preventing Pediatric Failures

25:28 Innovative Trial Design Insights

28:16 Outdated Clinical Trials Persist

32:53 US vs Europe: Payment & Regulation

38:14 Streamlining Drug Development Timelines

41:02 Startup's Rapid Growth Journey

43:42 Nuances in Medical Writing Explained

45:59 Documentation Workflow Experience

50:14 Insights on Clinical Trials and Investing

The Uprising Show Website: https://theuprisingshow.com/

Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/

Vivek Nanda's Twitter: https://x.com/vickks

TopHealth Media Website: https://tophealth.care/

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In this enlightening episode of The Uprising Show, host Vivek welcomes Dr. Eve Cunningham, the new Chief Medical Officer of Cadence. Join us as we dive into Dr. Cunningham's fascinating career journey from an OBGYN physician to a tech leader in healthcare innovation.

She shares her insights on the transformation of care delivery systems, embracing technology, and her exciting new role at Cadence—an innovative force scaling remote patient care. As they delve into the future of healthcare, Dr. Cunningham offers her perspective on the impact of AI and the importance of remote care as a standard practice.

Tune in to learn about the challenges and triumphs in healthcare innovation and what the future holds for this industry. Plus, hear a fun tidbit from Dr. Cunningham's past that you won't want to miss!

Timestamps:

00:00 Career Transition to Cadence Leadership

05:52 Doctors as Entrepreneurs

09:13 "Entrepreneurial Spirit in Medicine"

11:46 Pioneering Virtual Medical Education

14:25 Tech Decisions Without Clinician Input

17:28 Strategic Healthcare Integration Insights

22:40 Costly Chronic Disease Mismanagement

23:50 Remote Care for Elderly Management

30:18 Securing Sponsorship for Clinical Integration

31:27 Remote Care Delivery with Feedback

36:39 Executive Stakeholders in Health Systems

40:26 Building Digital Health Infrastructure

44:24 Cadence's Impact on Healthcare Costs

45:39 Reducing Healthcare Costs and Admissions

50:02 Encouraging Clinical Experimentation

53:21 Early Lisa Frank Model Mystery

55:21 Unique Market Positioning

Dr. Eve Cunningham - LinkedIn - https://www.linkedin.com/in/evecunninghammd/

Cadence - https://www.cadence.care/

The Uprising Show Website: https://theuprisingshow.com/

Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/

Vivek Nanda's Twitter: https://x.com/vickks

TopHealth Media Website: https://tophealth.care/